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Gosh guys I wish I could tell you a wonderful tip or technique but I really think it is luck and speed.  I did learn that you need to keep the tiles from getting anywhere near the right of the board right away, as that seems to shorten your game. I used Pinky's tip to click on one tile until it changed to the color I needed for big groups.
 
Try to knock out the big groups fast because it paralyzes the other team for a few seconds. If you can get that to happen right before the new column of tiles adds on at the point when you have it down to just a few last tiles, maybe that is they key?  I tried to make some big groups of colors working back and forth very quickly and then I would click on the big groups causing the other side to pause and then I was able to finally clear the board when all I had to do was change the color of one tile to yellow. I think that part is luck but if you have the skill and speed to get some big groups together but not click on them until the end that might do it.
 
 I hope this helps. Just keep at it because the odds are going to eventually go your way. I had to play it on and off for over 24 hours before I finally got it this morning. Good Luck! :)