I had the same problem. It turned out that Grimaldi sabotage the vendors and no more truffle powder. He comes on says something about showing you for interfering in the business and poof, you can't buy truffle powder anywhere. The truffle powder that I had in my inventory was still there and usable, but when you run out, that is it. You have to make other thing such as infusions.
I played for a while after hoping that the truffle powder would become available again, but it did not the last time I played. Don't know if you are ever able to buy truffle powder again.
if you are talking about the first edition of Chocolatier, that is a regular featuer of the game. After you reach the end and become Master Chocolatier all truffle powder disappears. It's almost as if Esteban Grimaldo stole it all. The only way to solve the poroblem is to create a new ID and play the game over again.
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